Cyclodextrins Deliver FA to Membranes Rapidly while Maintaining a Low Concentration of Unbound FA in Water
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Cytokine-induced fever in obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats.
In earlier work, we reported that genetically obese ( fa/ fa) Zucker rats exhibited significantly greater anorexia than did lean ( Fa/ Fa) Zucker rats to intracerebroventricular infusion of interleukin (IL)-1β. Here, we investigated the fever response of obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats to intracerebroventricular microinfusion of IL-1β as well as to the following other cytokines: ...
متن کاملA frequently used approach for adding FA at higher concentration is to complex the FA with albumin, which allows preparation of FA that is solubilized at millimolar
This article is available online at http://www.jlr.org A frequently used approach for adding FA at higher concentration is to complex the FA with albumin, which allows preparation of FA that is solubilized at millimolar concentrations. Although albumin is a physiologically relevant carrier of FA, careful consideration must be given to the facts that albumin can deliver impurities to cells and c...
متن کاملLean ( Fa/ Fa) but not obese ( fa/ fa) Zucker rats release cholecystokinin at PVN after a gavaged meal.
Neuropeptides play an important role in the integration of dietary signals. Cholecystokinin (CCK) has been implicated in regulating ingestive behavior, particularly satiety. The primary objective of this study was to examine whether the hyperphagia characteristic of obese ( fa/ fa) rats involves impaired neural CCK secretion. Dynamic release of CCK at the hypothalamic paraventricular nucleus (P...
متن کاملOntogeny of hyperphagia in the Zucker ( fa/ fa) rat.
The ontogeny of hyperphagic behavior in the Zucker fatty ( fa/ fa) rat was examined. Wild-type, +/ fa, and fa/ fapups aged postnatal day 5( P5), P9, P12, P15, and P18 were evaluated using a test that measured ingestive behavior independent of the dam. The independent ingestive test consisted of giving pups access to a test solution [half-and-half (cream and milk)] on a tissue on the floor of a ...
متن کاملCharacterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats.
Both insulin resistance and hyperinsulinemia have been reported to be independent risk factors for cardiovascular diseases. However, little is known regarding insulin signaling in the vascular tissues in insulin-resistant states. In this report, insulin signaling on the phosphatidylinositol 3-kinase (PI 3-kinase) and mitogen-activated protein (MAP) kinase pathways were compared in vascular tiss...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.659